ccm2-like is required for cardiovascular development as a novel component of the Heg-CCM pathway.

doi:10.1016/j.ydbio.2013.01.006

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Article

ccm2-like is required for cardiovascular development as a novel component of the Heg-CCM pathway.

Developmental biology - 1 Apr 2013

Rosen Jonathan N, Sogah Vanessa M, Ye Lillian Y, Mably John D

Abstract excerpt

The Heart of Glass-Cerebral Cavernous Malformation (Heg-CCM) pathway is essential for normal cardiovascular development in zebrafish and mouse. In zebrafish, the Heg-CCM pathway mutants santa(ccm1/san), valentine (ccm2/vtn), and heart of glass (heg) exhibit severely dilated hearts and inflow tracts and a complete absence of blood circulation. We identified a novel gene based on its sequence identity with ccm2,...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cardiovascular System
DNA Primers
Immunoblotting
In Situ Hybridization
KRIT1 Protein
Membrane Glycoproteins
Mice
Microfilament Proteins
Microscopy
Microtubule-Associated Proteins
Molecular Sequence Data

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Morpholinos

Phenotype

Proto-Oncogene Proteins

Reverse Transcriptase Polymerase Chain Reaction

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Identifiers

PMID: 23328253
DOI: 10.1016/j.ydbio.2013.01.006
PMCID: PMC4301579

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