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Article

ccm2-like is required for cardiovascular development as a novel component of the Heg-CCM pathway.

Developmental biology - 1 Apr 2013

Rosen Jonathan N, Sogah Vanessa M, Ye Lillian Y, Mably John D

Abstract excerpt

The Heart of Glass-Cerebral Cavernous Malformation (Heg-CCM) pathway is essential for normal cardiovascular development in zebrafish and mouse. In zebrafish, the Heg-CCM pathway mutants santa(ccm1/san), valentine (ccm2/vtn), and heart of glass (heg) exhibit severely dilated hearts and inflow tracts and a complete absence of blood circulation. We identified a novel gene based on its sequence identity with ccm2,...

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Identifiers

PMID: 23328253
DOI: 10.1016/j.ydbio.2013.01.006
PMCID: PMC4301579

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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