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Article

Forward genetics combined with unsupervised classifications identified zebrafish mutants affecting biliary system formation.

Developmental biology - 1 Aug 2024

Singh Divya Jyoti, Tuscano Kathryn M, Ortega Amrhen L, Dimri Manali, Tae Kevin, Lee William, Muslim Muslim A, Rivera Paz Isabela M, Liu Jay L, Pierce Lain X, McClendon Allyson, Gibson Isabel, Livesay Jodi, Sakaguchi Takuya F

Abstract excerpt

Impaired formation of the biliary network can lead to congenital cholestatic liver diseases; however, the genes responsible for proper biliary system formation and maintenance have not been fully identified. Combining computational network structure analysis algorithms with a zebrafish forward genetic screen, we identified 24 new zebrafish mutants that display impaired intrahepatic biliary network formation....

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Identifiers

PMID: 38729406
DOI: 10.1016/j.ydbio.2024.05.005
PMCID: PMC11983484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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