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Exploring Causal Association between Neuroticism Subclusters and Risk of Coronary Atherosclerosis: A Mendelian Randomization Analysis based on Genome-Wide Association Studies

2025-02-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Understanding the risk factors associated with coronary atherosclerosis (CA)—an evident cardiovascular disease—is vital. This study aimed to explore the causal relationship between neuroticism subclusters and CA, focusing on lipids as mediators, using genome-wide association studies and Mendelian randomization (MR). <h4>Methods and Results</h4> Instrumental variables were s...

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Literature Corpus work: 994f228f-73b2-5a7d-b326-24c6d3c03ddb
DOI: 10.1101/2025.02.19.25322578

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