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Article

Causal association between Neuroticism and risk of aortic aneurysm: A bidirectional two-sample Mendelian randomization study.

Journal of affective disorders - 15 Oct 2024

Wang Mengmeng, Mo Degang, Zhou Chi, Zhang Wenqiang, Chen Rui, Xu Jiachao, Zhang Ning, Yu Haichu

Abstract excerpt

BACKGROUND: The objective of this study was to analyze the causal relationship between Neuroticism and aortic aneurysm using Mendelian randomization (MR). The study aimed to establish a foundation for the development of effective prevention and treatment strategies. METHODS: Genetic association data for Neuroticism were obtained from the UK Biobank, which included 393,411 individuals and 11,968,760 single...

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Aortic Aneurysm
Genetic Predisposition to Disease
Genome-Wide Association Study
Mendelian Randomization Analysis
Neuroticism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 39059476
DOI: 10.1016/j.jad.2024.07.100

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