Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic evidence for the causal association of neuroticism with intracranial aneurysms: A Mendelian randomization study.

Neuroscience - 1 Nov 2024

Tan Jiacong, Zhu Huaxin, Zeng Yanyang, Li Jiawei, Zhao Yeyu, Li Meihua

Abstract excerpt

OBJECTIVE: The aim of this study was to assess the potential causal relationship between neuroticism and 12 neuroticism items with intracranial aneurysms (IAs) and aneurysmal subarachnoid hemorrhage (aSAH) using a two-sample Mendelian randomization (MR) approach. METHODS: Study data were obtained from the Genome-Wide Association Study (GWAS) pooled dataset, and we extracted summary statistics for neuroticism, 12...

Topics

Join the communities discussing this publication.

Genetic Predisposition to Disease
Genome-Wide Association Study
Intracranial Aneurysm
Mendelian Randomization Analysis
Neuroticism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Subarachnoid Hemorrhage

Source

Identifiers

PMID: 39260560
DOI: 10.1016/j.neuroscience.2024.09.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic evidence for the causal association of neuroticism with intracranial aneurysms: A Mendelian randomization study.PMID 39260560Read ↗

Causal association between Neuroticism and risk of aortic aneurysm: A bidirectional two-sample Mendelian randomization study.Semantic proximity Read ↗

Exploring Causal Association between Neuroticism Subclusters and Risk of Coronary Atherosclerosis: A Mendelian Randomization Analysis based on Genome-Wide Association StudiesSemantic proximity Read ↗

Phenome-wide Mendelian Randomization Analysis of Genetic Variants Linking Intracranial Aneurysm, Unruptured Aneurysm, and Subarachnoid HemorrhageSemantic proximity Read ↗

Effect of worry, depressed affect, and sensitivity to environmental stress owing to neurotic personality on MRI markers of cerebral small vessel disease: A univariable and multivariable Mendelian randomization study.Semantic proximity Read ↗

Causal influences of neuroticism on mental health and cardiovascular disease.Semantic proximity Read ↗

Modifiable lifestyle factors and risk of intracranial aneurysm: A univariate and multivariate Mendelian randomisation study.Semantic proximity Read ↗

Genetically Determined Levels of Serum Metabolites and Risk of Neuroticism: A Mendelian Randomization Study.Semantic proximity Read ↗

Drug classes affecting intracranial aneurysm risk: genetic correlation and Mendelian randomizationSemantic proximity Read ↗

Genetic variation mediating neuroticism's influence on cardiovascular diseases.Semantic proximity Read ↗

Bi-directional causal association between 17 neurosurgical diseases and three emotional disorders: perspective from Mendelian randomization analysisSemantic proximity Read ↗

Causal relationship between intracranial aneurysms and COVID-19: A bidirectional two-sample Mendelian randomization studySemantic proximity Read ↗

Gene-based association analysis identified 190 genes with polymorphisms affecting neuroticismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.