Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Personality disorders and cardiometabolic diseases: A Mendelian randomization study.

Medicine - 9 Jan 2026

Yang Wentao, Yang Zhaoqing, Xi Juemin, Bian Cheng, Cheng Zian

Abstract excerpt

Observational studies have suggested the associations between personality disorders (PDs) and cardiometabolic diseases (CMDs), though these may be biased by unmeasured confounding, including lifestyle factors or reverse causality. Mendelian randomization (MR) provides a novel approach to address these limitations by using genetic variants as instrumental variables, thereby minimizing environmental confounding and...

Topics

Join the communities discussing this publication.

Cardiovascular Diseases
Genetic Predisposition to Disease
Genome-Wide Association Study
Mendelian Randomization Analysis
Metabolic Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Personality Disorders

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 41517677
DOI: 10.1097/MD.0000000000046702
PMCID: PMC12795098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Personality disorders and cardiometabolic diseases: A Mendelian randomization study.PMID 41517677Read ↗

Causal links between personality disorders and schizophrenia: A Mendelian randomization study.Semantic proximity Read ↗

Psychiatric disorders and cardiovascular diseases: A mendelian randomization studySemantic proximity Read ↗

Causal relationships between blood lipids and major psychiatric disorders: Univariable and multivariable mendelian randomization analysis.Semantic proximity Read ↗

A Mendelian randomization study of the effect of mental disorders on cardiovascular diseaseSemantic proximity Read ↗

Metabolic disorders and risk of cardiovascular diseases: a two-sample mendelian randomization studySemantic proximity Read ↗

Exploring Causal Association between Neuroticism Subclusters and Risk of Coronary Atherosclerosis: A Mendelian Randomization Analysis based on Genome-Wide Association StudiesSemantic proximity Read ↗

Modifiable lifestyle factors influencing psychiatric disorders mediated by plasma proteins: A systemic Mendelian randomization studySemantic proximity Read ↗

Causal inference in psychiatric research: how to critically evaluate and interpret mendelian randomization studies.Semantic proximity Read ↗

Effect of worry, depression, and sensitivity to environmental stress owing to neurotic personality on risk of cardiovascular disease: A Mendelian randomization study.Semantic proximity Read ↗

Mendelian randomization for cardiovascular diseases: principles and applicationsSemantic proximity Read ↗

Causality between neuroticism personality clusters and female reproductive diseases in European population: a two-sample bidirectional mendelian randomization studySemantic proximity Read ↗

Causal effects between negative moods and cardiovascular diseases: a Mendelian randomization studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.