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Causal relationship between neuroticism and frailty: A bidirectional Mendelian randomization study.

Journal of affective disorders - 1 Sept 2024

Chen Qingyan, Gan Da, Zhang Yingjuan, Yan Runlan, Li Bei, Tang Wenbin, Han Shuang, Gao Yue

Abstract excerpt

BACKGROUND: Observational studies have shown that neuroticism is associated with frailty, but the causal relationship between them remains unclear. METHODS: A two-sample Mendelian randomization (MR) study was conducted to explore the bidirectional causal relationship between neuroticism (n = 380,506 for the primary analysis, n = 79,004 for the validation) and frailty (n = 175,226) using publicly available...

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Causality
Frailty
Genome-Wide Association Study
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 38788854
DOI: 10.1016/j.jad.2024.05.105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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