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Neuroticism as a protective factor for cardiomyopathy: A mediation Mendelian randomization study.

Journal of affective disorders - 15 Jun 2026

Wang Mengmeng, Teng Tianqi, Mo Degang, Chen Rui, Xu Jiachao, Dong Zihan, Zhang Ning, Yu Haichu

Abstract excerpt

BACKGROUND: The relationship between Neuroticism and cardiomyopathy (CM) remains underexplored, despite links to other cardiovascular conditions. OBJECTIVES: To investigate the causal effect of genetically predicted neuroticism on cardiomyopathy risk and to identify circulating protein mediators of this association using a two-step, proteome-wide mediation Mendelian randomization (MR) framework. METHODS: We...

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Cardiomyopathies
Genome-Wide Association Study
Mediation Analysis
Mendelian Randomization Analysis
Neuroticism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Protective Factors

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Identifiers

PMID: 41724399
DOI: 10.1016/j.jad.2026.121400

Genes

KLRC4
PRLH
THPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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