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Article

Immunomodulatory role of megakaryocytes in the hematopoietic niche of myeloproliferative neoplasms.

Haematologica - 1 Jul 2026

Yang Xiaoxi, Lee Sandy, Masarik Kyla, Ahmed Tameena, Zheng Lei, Zhan Huichun

Abstract excerpt

Myeloproliferative neoplasms (MPN) are clonal stem cell disorders characterized by dysregulated megakaryopoiesis and expansion of neoplastic hematopoietic stem cells (HSC). Megakaryocytes (MK) not only regulate HSC function, but also shape immune responses within the marrow niche. Using an aging murine model of MPN with MK-restricted JAK2V617F expression, we investigated the immunomodulatory roles of mutant MK....

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Disease Models, Animal
Hematopoietic Stem Cells
Immunomodulation
Janus Kinase 2
Megakaryocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myeloproliferative Disorders

Stem Cell Niche

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Identifiers

PMID: 41568522
DOI: 10.3324/haematol.2025.288948
PMCID: PMC13317882

Genes

PF4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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