Article

Revisiting the Role of the Leucine Plug/Valve in the Human ABCG2 Multidrug Transporter

2025-03-17

Abstract excerpt

In the human ABCG2 multidrug transporter a so called “leucin plug/valve” (aa. L554/L555) has been suggested to determine substrate exit and coupling of drug transport to ATPase activity. In this work we have analyzed the effects of selected var-iants in this region by expressing these variants both in mammalian and Sf9 insect cells. We found that in mammalian cells the L554A, L554F, L555F and a combina...

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Literature Corpus work: 9903cc87-d261-5e9c-90f1-531be3a95c0a
DOI: 10.20944/preprints202503.1238.v1

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