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Article

Arginine 383 is a crucial residue in ABCG2 biogenesis.

Biochimica et biophysica acta - 1 Jul 2009

Polgar Orsolya, Ediriwickrema Lilangi S, Robey Robert W, Sharma Ajay, Hegde Ramanujan S, Li Yongfu, Xia Di, Ward Yvona, Dean Michael, Ozvegy-Laczka Csilla, Sarkadi Balazs, Bates Susan E

Abstract excerpt

ABCG2 is an ATP-binding cassette half-transporter initially identified in multidrug-resistant cancer cell lines and recently suggested to play an important role in pharmacokinetics. Here we report studies of a conserved arginine predicted to localize near the cytoplasmic side of TM1. First, we determined the effect of losing charge and bulk at this position via substitutions with glycine and alanine. The R383G...

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Identifiers

PMID: 19406100
DOI: 10.1016/j.bbamem.2009.04.016
PMCID: PMC4163909

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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