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Article

The ABCG2/BCRP transporter and its variants - from structure to pathology.

FEBS letters - 1 Dec 2020

Sarkadi Balázs, Homolya László, Hegedűs Tamás

Abstract excerpt

The ABCG2 protein has a key role in the transport of a wide range of structurally dissimilar endo- and xenobiotics in the human body, especially in the tissue barriers and the metabolizing or secreting organs. The human ABCG2 gene harbors a high number of polymorphisms and mutations, which may significantly modulate its expression and function. Recent high-resolution structural data, complemented with molecular...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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PMID: 33015850
DOI: 10.1002/1873-3468.13947

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