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Article

Tumor-acquired somatic mutation affects conformation to abolish ABCG2-mediated drug resistance.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Mar 2024

Gose Tomoka, Rasouli Ali, Dehghani-Ghahnaviyeh Sepehr, Wen Po-Chao, Wang Yao, Lynch John, Fukuda Yu, Shafi Talha, Ford Robert C, Tajkhorshid Emad, Schuetz John D

Abstract excerpt

ABCG2 is an important ATP-binding cassette transporter impacting the absorption and distribution of over 200 chemical toxins and drugs. ABCG2 also reduces the cellular accumulation of diverse chemotherapeutic agents. Acquired somatic mutations in the phylogenetically conserved amino acids of ABCG2 might provide unique insights into its molecular mechanisms of transport. Here, we identify a tumor-derived somatic...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38387283
DOI: 10.1016/j.drup.2024.101066
PMCID: PMC11137617

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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