Article

The APOL1 variant p.N264K blocks ion flow by occluding a pore at the cell surface

2025-11-06

Abstract excerpt

<h4>ABSTRACT</h4> The APOL1 gene variants G1 and G2 are associated with an increased risk of APOL1-mediated kidney disease. A recently identified variant, p.N264K (M1), mitigates this risk of renal damage by abolishing APOL1-G2’s associated cytotoxicity. However, the molecular and structural basis of this protective effect remains incompletely understood. In this study, we first show that both the cytotoxic G2 an...

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Literature Corpus work: b5419728-f162-5a0a-b738-3254be370ac8
DOI: 10.1101/2025.11.05.686714

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