Article

Expression, Function and Trafficking of the Human ABCG2 Multidrug Transporter Containing Mutations in an Unstructured Cytoplasmic Loop

2023-09-07

Abstract excerpt

The human ABCG2 multidrug transporter plays a crucial role in the absorption and excretion of xeno- and endobiotics, contributes to cancer drug resistance and the development of gout. In this work we have analyzed the effects of selected variants, residing in a structurally unresolved cytoplasmic region (a.a. 354-367) of ABCG2, on the function and trafficking of this protein. A cluster of four lysines (K357-360) a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a66e0ab2-b083-5a8a-9a2e-2cd77a42022c
DOI: 10.20944/preprints202309.0514.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Expression, Function and Trafficking of the Human ABCG2 Multidrug Transporter Containing Mutations in an Unstructured Cytoplasmic LoopDOI 10.20944/preprints202309.0514.v1Read

The ABCG2/BCRP transporter and its variants - from structure to pathology.Semantic proximity Read

The transport pathway in the ABCG2 protein and its regulation revealed by molecular dynamics simulations.Semantic proximity Read

Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression.Semantic proximity Read

Transmembrane Domain Single-Nucleotide Polymorphisms Impair Expression and Transport Activity of ABC Transporter ABCG2.Semantic proximity Read

Single-nucleotide polymorphisms in a short basic motif in the ABC transporter ABCG2 disable its trafficking out of endoplasmic reticulum and reduce cell resistance to anticancer drugs.Semantic proximity Read

Arginine 383 is a crucial residue in ABCG2 biogenesis.Semantic proximity Read

Medically Important Alterations in Transport Function and Trafficking of ABCG2.Semantic proximity Read

Tumor-acquired somatic mutation affects conformation to abolish ABCG2-mediated drug resistance.Semantic proximity Read

Revisiting the Role of the Leucine Plug/Valve in the Human ABCG2 Multidrug TransporterSemantic proximity Read

Structure of the human multidrug transporter ABCG2.Semantic proximity Read

The ABCG family of membrane-associated transporters: you don't have to be big to be mighty.Semantic proximity Read

Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets.Semantic proximity Read