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Article

Hepatitis B virus polymerase restricts LINE-1 retrotransposition

2021-05-07

Abstract excerpt

Long interspersed element-1 (LINE-1, L1) retrotransposon composes about 17% of the human genome. However, genetic and biochemical interactions between L1 and hepatitis B virus (HBV) remain poorly understood. In this study, we found that HBV restricts L1 mobility without inhibiting the L1 promoter activity. Notably, HBV polymerase (Pol) strongly inhibited L1 retrotransposition in a reverse transcriptase (RT)-indepe...

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Identifiers and source

Literature Corpus work
98f3d5b7-faf9-52bd-8ae5-fc2308d04948
DOI
10.1101/2021.05.07.443105
Open publication

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Hepatitis B virus polymerase restricts LINE-1 retrotranspositionDOI 10.1101/2021.05.07.443105
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