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Article

Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity.

Nucleic acids research - 1 Jan 2014

Horn Axel V, Klawitter Sabine, Held Ulrike, Berger André, Vasudevan Ananda Ayyappan Jaguva, Bock Anja, Hofmann Henning, Hanschmann Kay-Martin O, Trösemeier Jan-Hendrik, Flory Egbert, Jabulowsky Robert A, Han Jeffrey S, Löwer Johannes, Löwer Roswitha, Münk Carsten, Schumann Gerald G

Abstract excerpt

LINE-1 (L1) retrotransposons are mobile genetic elements whose extensive proliferation resulted in the generation of ≈ 34% of the human genome. They have been shown to be a cause of single-gene diseases. Moreover, L1-encoded endonuclease can elicit double-strand breaks that may lead to genomic in...

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Identifiers

PMID: 24101588
DOI: 10.1093/nar/gkt898
PMCID: PMC3874205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24101588-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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