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Article

MicroRNA miR-128 represses LINE-1 (L1) retrotransposition by down-regulating the nuclear import factor TNPO1.

The Journal of biological chemistry - 15 Dec 2017

Idica Adam, Sevrioukov Evgueni A, Zisoulis Dimitrios G, Hamdorf Matthias, Daugaard Iben, Kadandale Pavan, Pedersen Irene M

Abstract excerpt

Repetitive elements, including LINE-1 (L1), comprise approximately half of the human genome. These elements can potentially destabilize the genome by initiating their own replication and reintegration into new sites (retrotransposition). In somatic cells, transcription of L1 elements is repressed by distinct molecular mechanisms, including DNA methylation and histone modifications, to repress transcription. Under...

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Identifiers

PMID: 28974576
DOI: 10.1074/jbc.M117.807677
PMCID: PMC5733588

Genes

TNPO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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MicroRNA miR-128 represses LINE-1 (L1) retrotransposition by down-regulating the nuclear import factor TNPO1.PMID 28974576Read ↗

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