Article

Condensation of LINE-1 is required for retrotransposition

2022-04-11

Abstract excerpt

LINE-1 (L1) is the only autonomously active retrotransposon in the human genome, and accounts for 17% of the human genome. The L1 mRNA encodes two proteins, ORF1p and ORF2p. ORF1p is a homotrimeric RNA-binding protein that plays a critical role in assembling functional L1 ribonucleoprotein (RNP) complexes. Here we show that condensation of ORF1p is required for L1 retrotransposition. Using a combination of biochem...

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Literature Corpus work: 5c375825-ff74-5163-813a-4003f1d6009a
DOI: 10.1101/2022.04.11.487880

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