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Article

BST2 Suppresses LINE-1 Retrotransposition by Reducing the Promoter Activity of LINE-1 5' UTR.

Journal of virology - 26 Jan 2022

Zhao Yifei, Du Juan, Wang Yu, Wang Qing, Wang Shaohua, Zhao Ke

Abstract excerpt

Endogenous retrotransposons are considered the "molecular fossils" of ancient retroviral insertions. Several studies have indicated that host factors restrict both retroviruses and retrotransposons through different mechanisms. Type 1 long interspersed elements (LINE-1 or L1) are the only active retroelements that can replicate autonomously in the human genome. A recent study reported that LINE-1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34730388
DOI: 10.1128/JVI.01610-21
PMCID: PMC8791264

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