Article

Persistent immune imprinting after XBB.1.5 COVID vaccination in humans

2023-11-30

Abstract excerpt

Immune imprinting - also known as ‘original antigenic sin’ - describes how the first exposure to a virus shapes the immunological outcome of subsequent exposures to antigenically related strains. SARS-CoV-2 Omicron breakthrough infections and bivalent COVID-19 vaccination were shown to primarily recall cross-reactive memory B cells and antibodies induced by prior mRNA vaccination with the Wuhan-Hu-1 spike rather t...

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Literature Corpus work: 98e9a28f-9df5-5887-9c87-fe55bf6a694a
DOI: 10.1101/2023.11.28.569129

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