Article

Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

2023-05-02

Abstract excerpt

The continuous emergence of highly immune evasive SARS-CoV-2 variants, like XBB.1.5 1,2 and XBB.1.16 3,4 , highlights the need to update COVID-19 vaccine compositions. However, immune imprinting induced by wildtype (WT)-based vaccination would compromise the antibody response to Omicron-based boosters 5-9 . Vaccination strategies that can counter immune imprinting are critically needed. In this study, we invest...

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Literature Corpus work: a563879a-a8a2-5ef7-b186-f52280bbb63f
DOI: 10.1101/2023.05.01.538516

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