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Immune imprinting and vaccine interval determine antibody responses to monovalent XBB.1.5 COVID-19 vaccination

17 May 2025

Abstract excerpt

As COVID-19 becomes endemic and vaccines are annually adapted, exposure intervals and immune imprinting become critical considerations for vaccination strategy. Imprinting by the ancestral spike protein affected bivalent Wuhan-Hu-1/BA.4-5 vaccine responses. We assess the persistence of imprinting in antibody responses to the more recent XBB.1.5 monovalent formulation. We quantified live virus-neutralizing...

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PMID: 40382525
DOI: 10.1038/s43856-025-00898-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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