Article

Prototype mRNA vaccines imprint broadly neutralizing human serum antibodies after Omicron variant-matched boosting

2024-01-04

Abstract excerpt

<h4>ABSTRACT</h4> Immune imprinting is a phenomenon in which an individual’s prior antigenic experiences influence responses to subsequent infection or vaccination. Here, using antibody depletion and multiplexed spike-binding assays, we characterized the type-specificity and cross-reactivity of serum antibody responses after mRNA vaccination in mice and human clinical trial participants. In mice, a single priming...

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Literature Corpus work: 0e70a14a-532f-5f39-ab9b-abe25f451701
DOI: 10.1101/2024.01.03.574018

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