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Article

Ancestral SARS-CoV-2 immune imprinting persists on RBD but not NTD after sequential Omicron infections

9 Dec 2024

Abstract excerpt

Whether Omicron exposures could overcome ancestral SARS-CoV-2 immune imprinting remains controversial. Here we analyzed B cell responses evoked by sequential Omicron infections in vaccinated and unvaccinated individuals. Plasma neutralizing antibody titers against ancestral SARS-CoV-2 and variants indicate that immune imprinting is not consistently induced by inactivated or recombinant protein vaccines. However,...

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PMID: 39807166
DOI: 10.1016/j.isci.2024.111557

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