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Article

Inhibiting epigenetic enzymes to improve atherogenic macrophage functions.

Biochemical and biophysical research communications - 12 Dec 2014

Van den Bossche Jan, Neele Annette E, Hoeksema Marten A, de Heij Femke, Boshuizen Marieke C S, van der Velden Saskia, de Boer Vincent C, Reedquist Kris A, de Winther Menno P J

Abstract excerpt

Macrophages determine the outcome of atherosclerosis by propagating inflammatory responses, foam cell formation and eventually necrotic core development. Yet, the pathways that regulate their atherogenic functions remain ill-defined. It is now apparent that chromatin remodeling chromatin modifying enzymes (CME) governs immune responses but it remains unclear to what extent they control atherogenic macrophage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25446073
DOI: 10.1016/j.bbrc.2014.11.029

Genes

HDAC3
ABCA1
ABCG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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