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Article

Quantitative Trait Locus Mapping of Macrophage Cholesterol Metabolism and CRISPR/Cas9 Editing Implicate an ACAT1 Truncation as a Causal Modifier Variant.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2018

Hai Qimin, Ritchey Brian, Robinet Peggy, Alzayed Alexander M, Brubaker Greg, Zhang Jinying, Smith Jonathan D

Abstract excerpt

OBJECTIVE: Cholesterol metabolism is a dynamic process involving intracellular trafficking, cholesterol esterification, and cholesterol ester hydrolysis. Our objective was to identify genes that regulate macrophage cholesterol metabolism. APPROACHES AND RESULTS: We performed quantitative trait loci mapping of free and esterified cholesterol levels and the ratio of esterified to free cholesterol in acetylated...

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Share to Acetyl-CoA C-Acetyltransferase
Share to Clustered Regularly Interspaced Short Palindromic Repeats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CRISPR-Associated Protein 9

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Source

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Identifiers

PMID: 29097366
DOI: 10.1161/ATVBAHA.117.310173
PMCID: PMC5746475

Genes

ACAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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