Article
Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry.
Circulation research - 8 Jun 2018
Winkels Holger, Ehinger Erik, Vassallo Melanie, Buscher Konrad, Dinh Huy Q, Kobiyama Kouji, Hamers Anouk A J, Cochain Clément, Vafadarnejad Ehsan, Saliba Antoine-Emmanuel, Zernecke Alma, Pramod Akula Bala, Ghosh Amlan K, Anto Michel Nathaly, Hoppe Natalie, Hilgendorf Ingo, Zirlik Andreas, Hedrick Catherine C, Ley Klaus, Wolf Dennis
Abstract excerpt
RATIONALE: Atherosclerosis is a chronic inflammatory disease that is driven by the interplay of pro- and anti-inflammatory leukocytes in the aorta. Yet, the phenotypic and transcriptional diversity of aortic leukocytes is poorly understood. OBJECTIVE: We characterized leukocytes from healthy and atherosclerotic mouse aortas in-depth by single-cell RNA-sequencing and mass cytometry (cytometry by time of flight) to...
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