Article

Canonical WNT signaling-driven DKC1 dysregulates sphingolipid biosynthesis and drives colorectal cancer.

2023-12-04

Abstract excerpt

<title>Abstract</title> <p>Aberrant activation of canonical WNT signaling has been implicated in colorectal cancer (CRC) progression. However, the complexity associated with WNT pathway poses challenges to consider it as an effective therapeutic target. Here, we employed a bottom-up approach and delineate the clinical significance of DKC1-driven CRC. We show higher DKC1 expression in ~88% of CRC patients associat...

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Literature Corpus work: de7a6254-74b9-5c68-b026-47ba22741426
DOI: 10.21203/rs.3.rs-3180701/v1

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