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Article

Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signaling.

Cell death and differentiation - 1 Nov 2009

Ciznadija D, Tothill R, Waterman M L, Zhao L, Huynh D, Yu R M, Ernst M, Ishii S, Mantamadiotis T, Gonda T J, Ramsay R G, Malaterre J

Abstract excerpt

Aberrant Wnt signaling mediated by mutations affecting APC (adenomatous polyposis coli) or beta-catenin initiates the majority of human colorectal cancers (CRC) and drives tumorigenesis through the activation of specific genes such as MYC. We report here a novel association whereby another oncoge...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19609274
DOI: 10.1038/cdd.2009.94

Genes

MYC
MYB
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19609274-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signaling.PMID 19609274Read ↗

MYC hyperactivates WNT signaling in APC/CTNNB1-mutated colorectal cancer cells through miR-92a-dependent repression of DKK3Semantic proximity Read ↗

Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice.Semantic proximity Read ↗

c‐Myb promotes growth and metastasis of colorectal cancer through c‐fos‐induced epithelial‐mesenchymal transitionSemantic proximity Read ↗

Myc deletion rescues Apc deficiency in the small intestine.Semantic proximity Read ↗

Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis.Semantic proximity Read ↗

Wnt signalling in the mouse intestine.Semantic proximity Read ↗

Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis.Semantic proximity Read ↗

Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferationSemantic proximity Read ↗

Inhibition of Intestinal Polyposis with Reduced Angiogenesis in ApcMin/+ Mice Due to Decreases in c-Myc ExpressionSemantic proximity Read ↗

Cooperation between MYC and β-catenin in liver tumorigenesis requires Yap/TazSemantic proximity Read ↗

The myc 3' wnt-responsive element suppresses colonic tumorigenesis.Semantic proximity Read ↗

Identification of endogenous Adenomatous polyposis coli interaction partners and β-catenin-independent targets by proteomicsSemantic proximity Read ↗

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