Article
The myc 3' wnt-responsive element suppresses colonic tumorigenesis.
Molecular and cellular biology - 1 May 2014
Konsavage Wesley M, Yochum Gregory S
Abstract excerpt
Mutations in components of the Wnt/β-catenin signaling pathway are commonly found in colorectal cancers, and these mutations cause aberrant expression of genes controlled by Wnt-responsive DNA elements (WREs). While the c-Myc proto-oncogene (Myc) is required for intestinal phenotypes associated with pathogenic Wnt/β-catenin signaling in vivo, the WREs that control Myc expression in this setting have yet to be...
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