Article
Disrupting ß-catenin dependent Wnt signaling activates an invasive gene program predictive of colon cancer progression
2019-06-11
Abstract excerpt
The recent classification of colon cancer into molecular subtypes revealed that patients with the poorest prognosis harbor tumors with the lowest levels of Wnt signaling. This is contrary to the long-standing understanding that overactive Wnt signaling promotes tumor progression from early initiation stages through to the later stages including invasion and metastasis. Here, we lower the levels of Wnt signaling in...
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Identifiers and source
- Literature Corpus work
- bd671eee-249f-5793-bfef-52f7a00df443
- DOI
- 10.1101/667030