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Article

c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1.

Molecular and cellular biology - 1 Jul 2007

Cowling Victoria H, D'Cruz Celina M, Chodosh Lewis A, Cole Michael D

Abstract excerpt

c-myc is frequently amplified in breast cancer; however, the mechanism of myc-induced mammary epithelial cell transformation has not been defined. We show that c-Myc induces a profound morphological transformation in human mammary epithelial cells and anchorage-independent growth. c-Myc suppresse...

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Share to Cell Transformation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intercellular Signaling Peptides and Proteins

Share to Mammary Glands, Human

Share to Proto-Oncogene Proteins c-myc

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Source

Open in PubMed Open full text

Identifiers

PMID: 17485441
DOI: 10.1128/MCB.02282-06
PMCID: PMC1951955

Genes

DKK1
SFRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17485441-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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