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Article

Targeting mitophagy in Parkinson's disease.

The Journal of biological chemistry - 1 Jan 2000

Clark Emily H, Vázquez de la Torre Aurelio, Hoshikawa Tamaki, Briston Thomas

Abstract excerpt

The genetics and pathophysiology of Parkinson's disease (PD) strongly implicate mitochondria in disease aetiology. Elegant studies over the last two decades have elucidated complex molecular signaling governing the identification and removal of dysfunctional mitochondria from the cell, a process of mitochondrial quality control known as mitophagy. Mitochondrial deficits and specifically reduced mitophagy are...

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Identifiers

PMID: 33372898
DOI: 10.1074/jbc.REV120.014294
PMCID: PMC7948953

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