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Article

Parkin-linked Parkinson's disease: From clinical insights to pathogenic mechanisms and novel therapeutic approaches.

Neuroscience research - 1 Oct 2020

Wasner Kobi, Grünewald Anne, Klein Christine

Abstract excerpt

With over 7 million patients worldwide, Parkinson's disease (PD) is becoming more prevalent as life span and industrialization increase. While the majority of cases are sporadic and present in individuals over 65, inherited mutations in Parkin can manifest in individuals as young as teenagers. The involvement of Parkin in neurodegeneration has been widely investigated and its role in mitophagy is undeniable. In...

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PMID: 32949666
DOI: 10.1016/j.neures.2020.09.001

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