Article

Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches

2021-02-02

Abstract excerpt

<h4>Summary</h4> Mitochondrial dysfunction is implicated in Parkinson disease (PD). Mutations in Parkin, an E3 ubiquitin ligase, can cause juvenile-onset Parkinsonism probably through impairment of mitophagy. Inhibition of the de-ubiquitinating enzyme USP30 may counter this effect to enhance mitophagy. Using different tools and cellular approaches, we wanted to independently confirm this claimed role for USP30. P...

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Literature Corpus work: 171f90ba-228f-5dd9-b8f7-c76229c146a9
DOI: 10.1101/2021.02.02.429344

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