Article

Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy

2021-04-28

Abstract excerpt

The deubiquitylase USP30 is an actionable target considered for treatment of conditions associated with defects in the PINK1/Parkin pathway leading to mitophagy. These include Parkinson’s disease and pulmonary fibrosis. We provide a detailed cell biological characterisation of a benzenesulphonamide molecule, compound 39, that has previously been reported to inhibit USP30 in an in vitro enzymatic assay. The curren...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d6fd478f-942e-5acc-92e2-c30c971dbf1d
DOI: 10.1101/2021.04.28.441730

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagyDOI 10.1101/2021.04.28.441730Read

A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylationSemantic proximity Read

USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanismsSemantic proximity Read

Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approachesSemantic proximity Read

High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagySemantic proximity Read

High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy.Semantic proximity Read

Molecular Symphony of Mitophagy: Ubiquitin‐Specific Protease‐30 as a Maestro for Precision Management of Neurodegenerative DiseasesSemantic proximity Read

Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson’s diseaseSemantic proximity Read

USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient and CCCP-stressed human iPSC-derived neuronsSemantic proximity Read

USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neuronsSemantic proximity Read

Targeting mitophagy in Parkinson's disease.Semantic proximity Read

USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell deathSemantic proximity Read

Dual role of USP30 in controlling basal pexophagy and mitophagySemantic proximity Read