Pharmacological PINK1 activation ameliorates Pathology in Parkinson’s Disease models

Abstract excerpt

<title>Abstract</title> <p>PINK1 loss-of-function mutations and exposure to mitochondrial toxins are causative for Parkinson’s disease (PD) and Parkinsonism, respectively. We demonstrate that pathological α-synuclein deposition, the hallmark pathology of idiopathic PD, induces mitochondrial dysfunction, and impairs mitophagy as evidenced by the accumulation of the PINK1 substrate pS65-Ubiquitin (pUb). We discover...

Topics

Open a Topic to create a Post that cites this publication.

• alpha-Synuclein
• Autophagy in Disease and Therapy
• Models, Neurological
• Parkinson Disease
• Parkinson's Disease Mechanisms and Treatments
• Protein Kinases
• Protein Multimerization
• Ubiquitin-Protein Ligases

Identifiers and source

Literature Corpus work

dbdd9139-4993-55ab-8a4b-468f12bc1d15

DOI

10.21203/rs.3.rs-4356493/v1