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Article

A transferrable and integrative type I-F Cascade for heterologous genome editing and transcription modulation

2021-02-09

Abstract excerpt

<h4>ABSTRACT</h4> The Class 1 type I CRISPR-Cas systems represent the most abundant and diverse CRISPR systems in nature. However, their applications for generic genome editing have been hindered by difficulties of introducing the class-specific, multi-component effectors in heterologous hosts for functioning. Here we established a transferrable Cascade system that enables stable integration and expression of a c...

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Literature Corpus work
98ba7c5a-7579-5332-89a0-a65a62ad2f6f
DOI
10.1101/2021.02.08.430362
Open publication

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A transferrable and integrative type I-F Cascade for heterologous genome editing and transcription modulationDOI 10.1101/2021.02.08.430362
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