Article

Synergistic CRISPR-Cas Antimicrobials through Essential and Defensive Gene Cotargeting in <i>Staphylococcus aureus</i>

2026-06-27

Abstract excerpt

<h4>ABSTRACT</h4> Multidrug-resistant pathogens pose a major threat to One Health. Within the past decade, CRISPR-Cas systems have been explored as sequence-specific antimicrobials. While chromosomal injury has been considered the primary mechanism underlying pathogen killing by CRISPR-Cas antimicrobials, the synergistic role of gene disruption together with chromosomal injuries remains poorly understood. In this...

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Literature Corpus work: 32e8e779-590f-5c31-8fd8-3afd74e1b543
DOI: 10.64898/2026.06.25.734632

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