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Reprogramming the endogenous type III-A CRISPR-Cas system for genome editing, RNA interference and CRISPRi screening in <i>Mycobacterium tuberculosis</i>

2020-03-09

Abstract excerpt

Mycobacterium tuberculosis ( M.tb ) causes the current leading infectious disease. Examination of the functional genomics of M.tb and development of drugs and vaccines are hampered by the complicated and time-consuming genetic manipulation techniques for M.tb. Here, we reprogrammed M.tb endogenous type III-A CRISPR-Cas10 system for simple and efficient gene editing, RNA interference and screening via simple d...

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Literature Corpus work
c73b0343-7962-5878-9688-ce6814d48088
DOI
10.1101/2020.03.09.983494
Open publication

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Reprogramming the endogenous type III-A CRISPR-Cas system for genome editing, RNA interference and CRISPRi screening in <i>Mycobacterium tuberculosis</i>DOI 10.1101/2020.03.09.983494
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