Article

Programming human cell type-specific gene expression via an atlas of AI-designed enhancers

2025-09-30

Abstract excerpt

Differentially active enhancers are key drivers of cell type specific gene expression. Active enhancers are found in open chromatin, which can be mapped at genome scale across tissue and cell types. Though incompletely understood, the relationship between chromatin accessibility and enhancer activity has been exploited to identify, model, and even design functional enhancers for selected cell types, but to what ex...

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Literature Corpus work: d0b4f0a6-42f8-53bf-ae7a-02e1d14728be
DOI: 10.1101/2025.09.30.679565

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