Article

Gene regulatory innovations from transposable elements in mammalian cerebellum development

2025-10-15

Abstract excerpt

<h4>ABSTRACT</h4> Transposable elements (TEs) are hypothesized to have driven gene regulatory innovation, yet their contributions to primate brain development at the cell type level remain largely unexplored. Using single-cell multiomics data for the cerebellum from human, macaque, marmoset, and mouse, we revealed that TE contributions to different cell types are shaped by differences in evolutionary constraint a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f5e4fc66-c980-5ceb-a6aa-6595309c5595
DOI: 10.1101/2025.10.15.682527

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gene regulatory innovations from transposable elements in mammalian cerebellum developmentDOI 10.1101/2025.10.15.682527Read

Comparative single cell epigenomic analysis of gene regulatory programs in the rodent and primate neocortexSemantic proximity Read

The evolution of gene regulation in mammalian cerebellum developmentSemantic proximity Read

Impact of non-LTR retrotransposons in the differentiation and evolution of Anatomically Modern HumansSemantic proximity Read

Young transposable elements rewired gene regulatory networks in human and chimpanzee hippocampal intermediate progenitorsSemantic proximity Read

Intrinsically linked lineage specificity of transposable elements, lncRNA genes, and transcriptional regulationSemantic proximity Read

Evolutionary transfer learning enables organism-wide inference of mammalian enhancer landscapesSemantic proximity Read

Conserved and divergent gene regulatory programs of the mammalian neocortex.Semantic proximity Read

Transposable elements drive species-specific and tissue-specific transcriptomes in human developmentSemantic proximity Read

MER57E3 transposable element subfamily co-opted for gene regulation in human early neural developmentSemantic proximity Read

3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural DevelopmentSemantic proximity Read

Transposable elements contribute to the spatiotemporal microRNA landscape in human brain developmentSemantic proximity Read

Integrated single-cell transcriptomic and epigenetic analyses of cell-state transition and lineage commitment in the embryonic mouse cerebellumSemantic proximity Read