Article

Gapped-kmer sequence modeling robustly identifies regulatory vocabularies and distal enhancers conserved between evolutionarily distant mammals

2023-10-06

Abstract excerpt

Gene regulatory elements drive many complex biological phenomena such as fetal development, and their mutations are linked to a multitude of common human diseases. The phenotypic impacts of regulatory variants are often tested using their conserved orthologous counterparts in model organisms such as mice. However, mapping human enhancers to conserved elements in mice remains a challenge, due to both rapid evolutio...

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Literature Corpus work: 0848b469-a7c2-551c-9441-bbc7b2b09ce2
DOI: 10.1101/2023.10.06.561128

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Gapped-kmer sequence modeling robustly identifies regulatory vocabularies and distal enhancers conserved between evolutionarily distant mammalsDOI 10.1101/2023.10.06.561128Read

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