Article

<i>TP53</i> loss initiates chromosomal instability in high-grade serous ovarian cancer

2021-03-12

Abstract excerpt

<h4>ABSTRACT</h4> High-grade serous ovarian cancer (HGSOC) originates in the fallopian tube epithelium and is characterized by ubiquitous TP53 mutation and extensive chromosomal instability (CIN). While the direct causes of CIN are errors during DNA replication and/or chromosome segregation, mutations in genes encoding DNA replication and mitotic factors are rare in HGSOC. Thus, the drivers of CIN remain undefin...

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Literature Corpus work: 788e8372-88b0-5e20-97ad-2c5e89913057
DOI: 10.1101/2021.03.12.435079

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