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Article

Chromosome instability is prevalent and dynamic in high-grade serous ovarian cancer patient samples

11 Mar 2021

Abstract excerpt

OBJECTIVE: High-grade serous ovarian cancer (HGSOC) is the most lethal gynaecological malignancy in women with a high level of mortality, metastatic disease, disease recurrence and multi-drug resistance. Many previous studies have focused on characterising genome instability in recurrent resistant HGSOC and while this has advanced our understanding of HGSOC, our fundamental knowledge of the mechanisms driving...

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PMID: 33714608
DOI: 10.1016/j.ygyno.2021.02.038

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