Isoform switching of CD47 induces macrophage-initiated cancer cell pyroptosis

Abstract excerpt

<title>Abstract</title> <p>Cancer cells escape immunosurveillance by expressing CD47, which binds to the SIRPα ligand on the surface of macrophages. Thus, CD47-targeted therapy represents a promising approach to overcoming cancer immune tolerance. Here we report that two major isoforms of CD47 exhibit distinct expression patterns in ovarian cancer and normal tissues. Single-cell and spatial transcriptome data ana...

Topics

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• Adenocarcinoma
• Biomarkers, Tumor
• Cell Line, Tumor
• Cell Movement
• Cell Proliferation
• Erythrocyte Function and Pathophysiology
• Gene Expression Regulation, Neoplastic
• Phagocytosis and Immune Regulation

Identifiers and source

Literature Corpus work

98453872-9754-5d8e-a67a-003ac9d88818

DOI

10.21203/rs.3.rs-6981061/v1