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Article

Recent Advances of Tumor Therapy Based on the CD47-SIRPα Axis

18 Apr 2022

Abstract excerpt

Cancer is still a major disease that is currently difficult for humans to overcome. When the expression of the cluster of differentiation 47 (CD47) is upregulated, tumor cells interact with the macrophage inhibitory receptor signal regulatory protein α (SIRPα) to transmit the "Don't eat me" signal, thereby avoiding phagocytosis by the macrophages. Therefore, when the CD47-SIRPα axis is inhibited, the macrophages'...

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PMID: 35436123
DOI: 10.1021/acs.molpharmaceut.2c00073

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