Article

SIRPα controls CD47-dependent platelet clearance in mice and humans

2023-12-10

Abstract excerpt

Over the last decade, more data has revealed that increased surface expression of the “don’t eat me” CD47 protein on cancer cells plays a role in immune evasion and tumor progression, with CD47 blockade emerging as a new therapy in immuno-oncology. CD47 is critical in regulating cell homeostasis and clearance, as binding of CD47 to the inhibitory receptor SIRPα can prevent phagocytosis and macrophage-mediated cell...

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Literature Corpus work: 1f203cb7-5940-531d-9089-17d969dae230
DOI: 10.1101/2023.12.09.570874

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