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Article

A Homogeneous SIRPα-CD47 Cell-Based, Ligand-Binding Assay: Utility for Small Molecule Drug Development in Immuno-oncology

2019-12-05

Abstract excerpt

<h4>ABSTRACT</h4> CD47 is an immune checkpoint protein that downregulates both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα. Biologics, including humanized CD47 monoclonal antibodies and decoy SIRPα receptors, that block the SIRPα-CD47 interaction, are currently being developed as cancer immunotherapy agents. However, adverse side effects and limited penetration of tumor tissu...

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Literature Corpus work
1c3d784b-7c6b-5a29-9e1c-1b7484fc5da0
DOI
10.1101/866145
Open publication

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